全息聚焦超声实现多靶点EV与MSC递送，促进缺血性卒中后神经血管修复
Holographic focused ultrasound enables multitarget EV and MSC delivery for neurovascular repair after ischemic stroke
上海科技大学团队开发全息聚焦超声技术，可在缺血性卒中后实现多靶点细胞外囊泡（EV）与间充质干细胞（MSC）递送，用于神经血管修复。该研究发表于Nature Communications，第一作者为Jia-Ji Pan、Chenyu Li、Xinya Yao。
Acknowledgements
We sincerely thank Dr. Liping Wang (Department of Neurology, Huadong Hospital, Fudan University) and Dr. Linyuan Zhang (Department of Neurology, Shanghai First People’s Hospital, Shanghai Jiao Tong University School of Medicine) for their clinical guidance. We would like to thank the support from HPC Platform and Medical Imaging Platform of ShanghaiTech University.
Funding
B.C. discloses support for the research of this work from National Natural Science Foundation of China (12504539), Natural Science Foundation of Shanghai (23ZR1442000), the Explorers Program of Shanghai (Basic Research Funding, 25TS1405800), and the start-up grant from ShanghaiTech University (2021F0209-000-09). J.P. discloses support for the research of this work from National Natural Science Foundation of China (82201459).
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Author notes
These authors contributed equally: Jia-Ji Pan, Chenyu Li, Xinya Yao.
Authors and Affiliations
TRUTH Lab, School of Biomedical Engineering, ShanghaiTech University, Shanghai, China
Jia-Ji Pan, Chenyu Li, Xinya Yao, Yan Wei, Lan Shen, Xiangkun Piao, Mingyu Wang & Bingbing Cheng
Shanghai Clinical Research and Trial Center, ShanghaiTech University, Shanghai, China
Chenyu Li & Bingbing Cheng
School of Life Science and Technology, ShanghaiTech University, Shanghai, China
Ji Hu
Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China
Guo-Yuan Yang
School of Physics, Harbin Institute of Technology, Harbin, China
Yanbo Pei
State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, Shanghai, China
Bingbing Cheng
Authors
- Jia-Ji Pan
- Chenyu Li
- Xinya Yao
- Yan Wei
- Lan Shen
- Xiangkun Piao
- Mingyu Wang
- Ji Hu
- Guo-Yuan Yang
- Yanbo Pei
- Bingbing Cheng
Corresponding authors
Correspondence to Jia-Ji Pan, Guo-Yuan Yang, Yanbo Pei or Bingbing Cheng.
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Pan, JJ., Li, C., Yao, X. et al. Holographic focused ultrasound enables multitarget EV and MSC delivery for neurovascular repair after ischemic stroke. Nat Commun (2026). https://doi.org/10.1038/s41467-026-78847-5
Received: 26 March 2026
Accepted: 02 October 2026
Published: 25 October 2026
DOI: https://doi.org/10.1038/s41467-026-78847-5
来源：Nature Biotechnology · nature.com