PNAS· Na WangRaksha PadakiSara-Jayne ThursbyRay-Whay Chiu YenLeslie M. CopeMalcolm V. BrockEdward GabrielsonHariharan EaswaranStephen B. BaylinMichelle Vazahttps://ror.org/00za53h95Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21287bhttps://ror.org/00za53h95Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287chttps://ror.org/00za53h95Department of Biostatistics, Johns Hopkins University School of Medicine, Baltimore, MD 21287dhttps://ror.org/00za53h95Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21287ehttps://ror.org/00za53h95Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287fDepartment of Epigenetics, Van Andel Research Institute, Grand Rapids, MI 49503·· 22 天前AI 评分42
慢性香烟烟雾暴露诱导不同干细胞状态，驱动遗传驱动基因特异性的非小细胞肺癌亚型
Chronic cigarette smoke exposure induces distinct stem cell states driving genetic driver–specific non–small cell lung cancer subtypes
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研究发现慢性香烟烟雾暴露诱导出不同的肺祖细胞干细胞状态，重塑其发育轨迹，使其对特定致癌事件产生依赖，进而驱动遗传驱动基因特异性的非小细胞肺癌亚型。该结果揭示慢性炎症如何推动不同肺祖细胞群体演化，为理解吸烟相关肺癌的亚型分化提供依据。
来源：PNAS · pnas.org