Bristol Myers Squibb 多发性硬化 CAR-T 试验中一名患者死亡
STAT+: Patient dies in Bristol Myers Squibb autoimmune CAR-T trial
Bristol Myers Squibb 周五披露，其研究性 CAR-T 疗法在一项针对多发性硬化的 Phase 1 试验中有一名患者死亡。该患者出现标准自免治疗无法缓解的运动症状，随后接受强效免疫抑制剂，发生脓毒性肺炎后死亡。Bristol 在给 STAT 的声明中称，该患者在接受 CAR-T 前已因一系列其他并发症接受治疗，这使判断问题根本原因变得困难。
Elaine’s stories explore the boom in new obesity treatments, new drug payment models, the ways companies are affected by FDA changes, and the emerging psychedelics drug sector. She co-writes The Readout newsletter, and co-hosts STAT’s weekly biotech podcast, The Readout Loud. You can reach Elaine on Signal at elaineywchen.70.
Bristol Myers Squibb on Friday reported that one patient died after receiving its investigational CAR-T therapy in an early autoimmune trial, adding to safety concerns about a growing field of research.
In a Phase 1 trial that tested the therapy in multiple sclerosis, a condition that causes muscle weakness and extreme fatigue, the patient experienced motor symptoms that did not resolve with standard autoimmune treatments. They were then given a potent immunosuppressant, but developed septic pneumonia and died, Bristol said in a press release.
In a subsequent statement sent to STAT, Bristol said this patient was treated for a series of other complications prior to receiving the CAR-T therapy, “confounding our ability to determine the root cause of the issue.”
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来源：STAT News · statnews.com