PNAS· Chen-Jun GuoYu-Fen WuShu-Ying GuoYou FuWei WangJi-Long Liuahttps://ror.org/030bhh786School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, Chinabhttps://ror.org/052gg0110Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom·· 18 天前AI 评分26
基于反应的冷冻电镜解析 CTP 合酶催化的连续构象谱
Reaction-based cryo-EM resolves the continuous conformational spectrum of CTP synthase catalysis
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研究提出基于反应的冷冻电镜方法，在天然条件下捕捉 CTP 合酶催化过程中的连续构象谱，突破传统方法依赖抑制剂或底物类似物将动态机器冻结为静态状态的限制。该工作发表于 PNAS 第 123 卷第 42 期。
来源：PNAS · pnas.org