尿液cfRNA液体活检用于膀胱癌检测
Urine cfRNA liquid biopsy for bladder cancer
一种名为uRARE-seq的尿液cfRNA液体活检方法可对膀胱癌进行无创检测与分子特征分析，相关研究发表于Nature Medicine。该方法通过随机引物与亲和捕获富集尿液cfRNA片段并测序，在包括局限性膀胱癌、前列腺腺癌和肾细胞癌患者及健康人中识别出各肿瘤类型特有的富集基因集。膀胱癌患者的尿液cfRNA谱与配对组织样本高度一致，显示其检测肿瘤相关分子改变的能力。
- Research Highlight
- Published: 27 October 2026
Bladder cancer
Nature Reviews Urology (2026) Cite this article
A new study in Nature Medicine describes urine random priming and affinity capture of cell-free RNA (cfRNA) fragments for enrichment analysis by sequencing (uRARE-seq), a liquid biopsy approach for urine cfRNA analysis, and evaluates its potential for non-invasive detection and molecular characterization of bladder cancer.
The authors used uRARE-seq to analyse urine cfRNA samples from patients with genitourinary cancers, including localized bladder cancer, prostate adenocarcinoma and renal cell carcinoma, and from healthy individuals. Distinct gene sets enriched in each tumour type were identified, and the remainder of the study focused on bladder cancer. In this setting, urine cfRNA profiles closely mirrored those of matched tissue samples, underscoring the ability of uRARE-seq to detect tumour-associated molecular alterations.
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Nature Reviews Urology http://www.nature.com/nrurol/
Maria Chiara Masone
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- Maria Chiara Masone
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Correspondence to Maria Chiara Masone.
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Cite this article
Masone, M.C. Urine cfRNA liquid biopsy for bladder cancer. Nat Rev Urol (2026). https://doi.org/10.1038/s41585-026-01211-1
Published: 27 October 2026
Version of record: 27 October 2026
DOI: https://doi.org/10.1038/s41585-026-01211-1
来源：Nature Biotechnology · nature.com