Cell· Min-Hwan Sohn, Danilo Dubocanin, Mitchell R. Vollger, Youngjun Kwon, Anna Minkina, Katherine M. Munson, Samuel F.M. Hart, Jane E. Ranchalis, Nancy L. Parmalee, Adriana E. Sedeño-Cortés, Jeffrey Ou, Shane J. Neph, Natalie Y.T. Au, Stephanie Bohaczuk, Brianne Carroll, Christian D. Frazar, William T. Harvey, Kendra Hoekzema, Meng-Fan Huang, Caitlin N. Jacques, Dana M. Jensen, J. Thomas Kolar, Rosa Lee, Jiadong Lin, Kelsey Loy, Taralynn Mack, Yizi Mao, Matthew W. Mitchell, Meranda M. Pham, Laura B. Scheinfeldt, Gretchen Smith, Erica Ryke, Joshua D. Smith, Lila Sutherlin, Elliott G. Swanson, Jeffrey M. Weiss, SMaHT Assembly WG, Claudia M.B. Carvalho, Tim H.H. Coorens, Kelley Harris, Chia-Lin Wei, Evan E. Eichler, Nicolas Altemose, James T. Bennett, Andrew B. Stergachis·· 13 天前AI 评分34
癌症体细胞突变负荷与功能影响的端粒到端粒图谱
A telomere-to-telomere map of somatic mutation burden and functional impact in a cancer
AI 导读
一项端粒到端粒近完整的二倍体组装结合配对黑色素瘤的深度长读长测序显示，16%的体细胞变异位于GRCh38缺失的序列中。卫星重复序列吸收紫外线损伤，动粒结合结构域同时累积遗传与表观遗传变异，体细胞表观突变主导了改变的调控景观。
来源：Cell · cell.com