Xtalks 网络研讨会：酶替代疗法生产中如何保持酶活性

In this free webinar, learn how manufacturing strategies can help preserve enzymatic activity throughout enzyme replacement therapy development and scale-up. The featured speaker will discuss protein folding, stability, analytical characterization and purification approaches that support enzyme function and product quality. Attendees will also explore how process monitoring and characterization can help maintain consistent enzyme performance across commercial manufacturing.

, /PRNewswire/ -- Enzyme replacement therapies have transformed the treatment landscape for many rare genetic and metabolic disorders by addressing enzyme deficiencies that drive disease progression. By supplying a functional version of a missing or deficient enzyme, these therapies can restore critical biological processes and improve patient outcomes. However, developing and manufacturing enzyme-based biologics presents unique challenges beyond those of many other protein therapeutics. This webinar explores the strategies used to preserve enzyme functionality across the manufacturing lifecycle.

The featured speaker will discuss the key development and manufacturing considerations involved in bringing enzyme replacement therapies from early development through commercial manufacturing. Attendees will gain insight into the scientific factors that influence enzyme functionality, including protein folding, stability, structural integrity and post-translational modifications. The session will explore why maintaining enzymatic activity is a critical quality attribute and how development teams evaluate and monitor activity throughout the program lifecycle.

The webinar will also examine manufacturing strategies designed to preserve enzyme performance during production, including expression system selection, analytical methods used to assess structural and functional characteristics and downstream purification approaches that minimize activity loss while achieving product quality requirements. Because enzyme function can be affected by subtle changes in process conditions, special attention will be given to process development considerations that support enzyme stability throughout manufacturing.

As programs progress toward larger manufacturing scales, development teams must ensure that enzymatic activity remains consistent across batches and production campaigns. The session will review process monitoring, activity-focused analytical testing and process characterization strategies that help maintain product performance during commercial manufacturing. Attendees will also hear a real-world example of how process optimization and purification improvements helped preserve catalytic activity and support successful manufacturing scale-up.

Register for this webinar to learn how enzyme replacement therapies can maintain enzymatic activity through development, scale-up and commercial manufacturing.

Join Dave Briggs, PhD, MSAT Principal Scientist, Late Stage/Commercial, Avid Bioservices, for the live webinar on Thursday, November 12, 2026, at 12pm EST (6pm CET).

For more information, or to register for this event, visit Enzyme Therapy Manufacturing: Preserving Activity Through Production.

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