基质衍生低致敏性：Beta vulgaris 多酚与甜菜醛酸调控 PR-10 过敏原的潜在作用

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Published: 30 October 2026

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Abstract

Cold-pressed apple, carrot, and celery juices retain native PR-10 allergens associated with Pollen-Food Allergy Syndrome, whereas thermal processing can alter allergen recognition while compromising heat-sensitive nutrients and sensory quality. We propose matrix-derived hypoallergenicity, a framework in which food-matrix chemistry may regulate allergen accessibility. Using beetroot (Beta vulgaris) as a model matrix, we examine two chemically plausible pathways, polyphenol-derived quinone modification and betalamic-acid-mediated carbonyl chemistry. Neither pathway has been validated in authentic juice systems. This perspective, therefore, defines a testable framework for modulating allergen behavior while preserving nutritional and sensory quality.

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This research received no external funding. The authors used generative artificial intelligence and large language models to improve language, readability, and flow, and to paraphrase and refine specific sections of the manuscript to ensure clarity and academic tone. The final output was critically reviewed, verified, and approved by the authors, who assume full responsibility for the accuracy and integrity of the work.

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Authors and Affiliations

Department of Food Sciences and Technology, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Parisa Mostashari & Motahareh Hashemi Moosavi
Research and Development Unit, Dina Pharmed Pharmaceutical Co, Tehran, Iran
Parisa Mostashari & Reza Hasanzadeh
Department of Biomedical Engineering, Ankara University, Ankara, Türkiye
Ismail Eş
Integrated Technologies Research Center (BÜTAM), Ankara University, Ankara, Türkiye
Ismail Eş
Food Health Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
Amin Mousavi Khaneghah

Authors

Parisa Mostashari
Motahareh Hashemi Moosavi
Ismail Eş
Reza Hasanzadeh
Amin Mousavi Khaneghah

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Correspondence to Amin Mousavi Khaneghah.

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Mostashari, P., Moosavi, M.H., Eş, I. et al. Matrix-derived hypoallergenicity: potential roles of Beta vulgaris polyphenols and betalamic acid in PR-10 allergen modulation. npj Sci Food (2026). https://doi.org/10.1038/s41538-026-01071-4

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Received: 16 June 2026
Accepted: 11 August 2026
Published: 30 October 2026
DOI: https://doi.org/10.1038/s41538-026-01071-4