Cell· Deepali L. Kundnani, Yeunsoo Lee, Taehwan Yang, Tyler P. Warner, Francisco Martinez-Figueroa, Tejasvi Channagiri, Penghao Xu, Ryan A. Eckerty, Mo Sun, Supreet Randhawa, Youngkyu Jeon, Stefania Marsili, Gary Newnam, Yilin Lu, Miharu Yasumuro, Ashlesha Gogate, Vivian S. Park, Sijia Tao, Justin A. Ling, Ryohei Chiba, Hiroyoshi Matsumura, Ryo Uehara, Jonathan M. Fogg, Lynn Zechiedrich, Raymond F. Schinazi, Zachary F. Pursell, Abdulmelik Mohammed, Patricia L. Opresko, Bret D. Freudenthal, Baek Kim, Soojin V. Yi, Nataša Jonoska, Francesca Storici·· 2026-08-28AI 评分30
人类核核糖体揭示DNA嵌入核糖核苷酸作为转录相关DNA超螺旋的表观遗传调控因子
Human nuclear ribomes reveal DNA-embedded ribonucleotides as epigenetic modulators of transcription-associated DNA supercoiling
AI 导读
人类核核糖体研究显示，DNA嵌入的核糖核苷酸在启动子相关调控元件处积累，并随转录活性增强而增多。RNase H2与Top1加工这些核糖核苷酸以调节DNA超螺旋，揭示了一种此前未被认识的表观遗传机制。
来源：Cell · cell.com